|Generic Modafinil (Provigil)
Modafinil increases the nervous system performance, enhances cognitive functions, improves memory, attention, and physical strength. Learn more about it from this article.
Modafinil is a psychostimulant that accelerates vital body functions. It was developed in the late 1980s by the American drug manufacturer Cephalon to treat narcolepsy (a condition in which people suddenly fall asleep during the daytime).
Today, Modafinil is sold as a prescription drug to treat narcolepsy in adults. The recommended starting dose is 200 mg per day. A single dose should not exceed 400 mg.
In addition to narocolepsy, Modafinil may be used to treat other conditions that also cause daytime sleepiness. These include attention and memory deficit disorders, Alzheimer's disease, depression, etc.
Properties and Mechanism of Action
Modafinil affects different areas of the brain. Probably the most important effect is the increase in the speed of mental reactions. This effect is caused by the lower part of the diencephalon – the hypothalamus, which activates nerve pathways. Orexin/hypocretin act as mediator substances and play an important role in regulating sleep-wake patterns.
In addition, the substance activates sympathetic alpha 1 receptors of the central nervous system, increases the activity of glutamine and histamine transmitters, and enhances the effects of serotonin in the cerebral cortex. It also reduces the activity of those inhibitory nerve cells in which gamma-aminobutyric acid acts as a mediator. However, the exact mechanism by which Modafinil promotes wakefulness is unknown.
How Quickly Does the Drug Begin to Act?
In most cases, patients feel the effects of Modafinil within half an hour after taking it. However, this indicator may vary depending on the individual characteristics of the body. Age, body weight, diet, and the presence of certain diseases may affect the rate at which it is absorbed.
Modafinil is generally well tolerated at therapeutic doses. However, it can still cause some undesirable effects, for example:
If you experience any unwanted symptoms, feel free to contact your healthcare provider and find out how to continue treatment.
According to the instruction, it is important to consult a doctor before taking Modafinil. This is especially true for those who have a hypersensitivity to the active substance or other components of the drug (lactose, lactose monohydrate, etc.), suffer from heart disease (left ventricular hypertrophy, mitral valve prolapse, etc.), and take other psychostimulants.
Modafinil may reduce the effectiveness of some contraceptives, which may lead to unplanned pregnancy. When combined with yohimbine hydrochloride (a natural fat burner), it causes a dangerous increase in heart rate and blood pressure. The drug should also not be combined with alcohol. Otherwise, the risk of side effects increases significantly.
The active substance Modafinil may speed up the breakdown of certain medications and thereby reduce their effect. These include:
The combined use of the drug with blood thinning agents (for example, Warfarin) requires regular blood clotting checks. Hormonal contraceptives may reduce the effect of Modafinil. Interaction with anticonvulsants is also possible.
Modafinil may alter the ability to respond because it affects the central nervous system. Patients taking the drug should wait for their individual response to the drug, and then discuss with their doctor whether they can be active road users during the treatment cycle.
Modafinil is a popular medication that helps combat daytime sleepiness caused by narcolepsy. It stimulates breathing and blood circulation, improves the work of the central nervous system, activates the integrative activity of the brain, that is, improves memory, concentration, and thinking. In other words, it is a psychostimulant that speeds up the body's vital functions.
Given the large number of influences and effects, it is not at all surprising that people involved in various fields of activity want to buy Modafinil today. The drug is well tolerated and does not cause addiction, unlike other drugs with a similar mechanism of action.